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Search results “Determining x linkedin or autosomal dominant”
Autosomal and X Linked Inheritance
 
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This lecture explains about the the autosomal and x linked inheritance. This video explains the properties of sex linked inheritance and the genetics pedigree. Autosomal trait is the one where the gene responsible for the trait is carried by Autosomes or body cell chromosomes. Sex linked trait or X linked trait is the one where the gene responsible for the trait is carried by X chromosomes. So most of the X linked trait is predominant ion male as males have only one X chromosome. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching the video lecture on Autosomal and X Linked Inheritance.
Views: 80709 Shomu's Biology
Pedigree Analysis methods - dominant, recessive and x linked pedigree
 
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Pedigree analysis by suman bhattacharjee - This lecture explains about the different rules of pedigree analysis. It explains how to find a pedigree based on characteristics with examples as dominant pedigree, recessive pedigree and x linked pedigree. Dominant inheritance - affect shown in every generation recessive inheritance - skips generation X linked recessive trait - Male offspring are affected more. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching
Views: 128016 Shomu's Biology
Pedigree analysis | How to solve pedigree problems?
 
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Pedigree analysis technique and rule - This lecture explains how to solve pedigree problems. With the help of few easy tricks and techniques you can solve any pedigree problems in minutes by applying the knowledge of pedigree analysis described in this video lecture. So watch this video and solve pedigree problems fast. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching the genetics lecture on Pedigree analysis and How to solve pedigree problems?
Views: 365996 Shomu's Biology
Pedigree probability problems | Risk calculation
 
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Pedigree probability problems - lecture explains about how to solve genetics probability problems on pedigree analysis . this video lecture explains the Pedigree probability problems with example. Here I will share the trick about how to solve those Pedigree problems associated with probability. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching the genetics lecture on how to solve Pedigree probability problems.
Views: 73492 Shomu's Biology
How to solve genetics probability problems
 
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This genetics lecture explains How to solve genetics probability problems with simpler and easy tricks and this video also explains when to use addition or multiplication rule to solve probability problems in genetics. So watch this video lecture to learn how to solve genetics problems with probability and risk calculations using addition and multiplication rule. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching the genetics lecture on How to solve genetics probability problems.
Views: 161615 Shomu's Biology
13. Sex linked inheritance
 
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For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html Inheritance is the practice of passing on property, titles, debts, rights and obligations upon the death of an individual. It has long played an important role in human societies. The rules of inheritance differ between societies and have changed over time. The term is also used to refer to the passing of characteristics, for example, genetically or in computing. X-linked dominant Main article: X-linked dominant X-linked dominant disorders are caused by mutations in genes on the X chromosome. Only a few disorders have this inheritance pattern, with a prime example being X-linked hypophosphatemic rickets. Males and females are both affected in these disorders, with males typically being more severely affected than females. Some X-linked dominant conditions, such as Rett syndrome, incontinentia pigmenti type 2 and Aicardi syndrome, are usually fatal in males either in utero or shortly after birth, and are therefore predominantly seen in females. Exceptions to this finding are extremely rare cases in which boys with Klinefelter syndrome (47,XXY) also inherit an X-linked dominant condition and exhibit symptoms more similar to those of a female in terms of disease severity. The chance of passing on an X-linked dominant disorder differs between men and women. The sons of a man with an X-linked dominant disorder will all be unaffected (since they receive their father's Y chromosome), and his daughters will all inherit the condition. A woman with an X-linked dominant disorder has a 50% chance of having an affected fetus with each pregnancy, although it should be noted that in cases such as incontinentia pigmenti, only female offspring are generally viable. In addition, although these conditions do not alter fertility per se, individuals with Rett syndrome or Aicardi syndrome rarely reproduce.[citation needed] X-linked recessive Main article: X-linked recessive X-linked recessive conditions are also caused by mutations in genes on the X chromosome. Males are more frequently affected than females, and the chance of passing on the disorder differs between men and women. The sons of a man with an X-linked recessive disorder will not be affected, and his daughters will carry one copy of the mutated gene. A woman who is a carrier of an X-linked recessive disorder (XRXr) has a 50% chance of having sons who are affected and a 50% chance of having daughters who carry one copy of the mutated gene and are therefore carriers. X-linked recessive conditions include the serious diseases hemophilia A, Duchenne muscular dystrophy, and Lesch-Nyhan syndrome, as well as common and less serious conditions such as male pattern baldness and red-green color blindness. X-linked recessive conditions can sometimes manifest in females due to skewed X-inactivation or monosomy X (Turner syndrome). Y-linked Main article: Y linkage Y-linked disorders are caused by mutations on the Y chromosome. Because males inherit a Y chromosome from their fathers, every son of an affected father will be affected. Because females only inherit an X chromosome from their fathers, and never a Y chromosome, female offspring of affected fathers are never affected. Since the Y chromosome is relatively small and contains very few genes, relatively few Y-linked disorders occur.[citation needed] Often, the symptoms include infertility, which may be circumvented with the help of some fertility treatments. Examples are male infertility.[citation needed] Source of the article published in description is Wikipedia. I am sharing their material. Copyright by original content developers of Wikipedia. Link- http://en.wikipedia.org/wiki/Main_Page PPT source: All the PowerPoint material is from Sciencegeek.net. Copyright by sciencegeek.net. Link- http://www.sciencegeek.net/Biology/Powerpoints.shtml
Views: 36030 Shomu's Biology
Gene mapping in bacteria | hfr mating problem 1 | CSIR UGC NET exam | practice problems
 
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This bacterial gene mapping lecture explains about Interrupted mating experiment problem and how to map hfr genes and use of hfr strain in bacterial gene mapping. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching
Views: 45516 Shomu's Biology
Difference between multiple alleles and polygenic inheritance
 
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Multiple alleles vs polygenic inheritance - This lecture explains about the difference between multiple alleles and polygenic inheritance. Alleles refer to different versions of the same gene. So a single gene can have multiple alleles. For example in fruit flies there is a single gene that controls eye color, and the eye color of the fly depends on the alleles they have for that gene (since they have two copies of every gene, being diploid). A polygenic trait refers to any inheritable trait that is controlled by multiple genes, and each of these genes can have multiple alleles. For example, eye color in humans is a polygenic trait. There are at least three different genes, each with multiple alleles, that determine eye color in humans. Polygenic traits don't follow patterns of mendelian inheritance. So in summation the difference is multiple alleles refers to different versions of one gene and polygenic traits refers to a single trait which is controlled by multiple genes (each with multiple alleles). Source: Yahoo answers. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching
Views: 30783 Shomu's Biology
Mechanism of Sex Chromosome - Chromosomal Basis of Inheritance - Biology Class 12
 
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Mechanism of Sex Chromosome Video Lecture of Chromosomal Basis of Inheritance Chapter from Biology Class 12 Subject for HSC, CBSE & NEET. Watch Previous Videos of Chapter Chromosomal Basis of Inheritance:- 1) Chromosomal Theory of Inheritance - Chromosomal Basis of Inheritance - Biology Class 12 - https://www.youtube.com/watch?v=r_nYXyaN_3I 2) Klinefelter Syndrome - Chromosomal Basis of Inheritance - Biology Class 12 - https://www.youtube.com/watch?v=REN5PgwBwQw Watch Next Videos of Chapter Chromosomal Basis of Inheritance:- 1) Turner Syndrome - Chromosomal Basis of Inheritance - Biology Class 12 - https://www.youtube.com/watch?v=JXtyDh2XHWI Access the Complete Playlist of Class 12 Biology:- http://gg.gg/biologyclass-12 Access the Complete Playlist of Chromosomal Basis of Inheritance:- http://gg.gg/Chromosomal-Basis-of-Inheritance Subscribe to Ekeeda Channel to access more videos:- http://gg.gg/Subscribe-Now #ChromosomalBasisofInheritance #Biologyclass12 #class12Biology #Biologyclass12th #Biologyforclass12 #EkeedaOnlineLectures #EkeedaVideoLectures #EkeedaVideoTutorial Thanks For Watching. You can follow and Like us on following social media. Website - http://ekeeda.com Parent Channel - https://www.youtube.com/c/ekeeda Facebook - https://www.facebook.com/ekeeda Twitter - https://twitter.com/Ekeeda_Video LinkedIn- https://www.linkedin.com/company-beta/13222723/ Instgram - https://www.instagram.com/ekeeda_/ Pinterest - https://in.pinterest.com/ekeedavideo You can reach us on [email protected] Happy Learning : )
Views: 213 Ekeeda
Penetrance genetics (penetrance and expressivity problem)
 
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This genetics lecture explains about the penetrance and expressivity. It also explains a mathematical problem involving penetrance calculations. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Remember Shomu’s Biology is created to spread the knowledge of biology by sharing through all this biology lecture videos and animations presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman
Views: 22170 Shomu's Biology
Loss of function and gain of function mutation | oncogenes and tumor suppressor genes
 
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This lecture on gene mutation explains about the loss of function and the gain of function mutation. This lecture explains the process of loss of function mutation and gain of function mutation separately and it also explains the effects of gain of function and gain of function mutation in details. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching
Views: 18072 Shomu's Biology
Dominant allele vs recessive allele | genetics lecture 4
 
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Genetics lecture 4 - dominant vs recessive allele - This genetics lecture explains about the difference between the properties of dominant allele and recessive allele. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Remember Shomu’s Biology is created to spread the knowledge of biology by sharing through all this biology lecture videos and animations presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman
Views: 5777 Shomu's Biology
Dihybrid Crosses and Linked Genes.mov
 
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Biology teacher Andrew Douch (Douchy) Explains how to determine from a dihybrid test cross, whether two gene loci are linked or assort independently.
Views: 79275 Andrew Douch
Genetics lecture 13 | Mendelian law in human genetics
 
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Genetics lecture 13 - This lecture explains about the Mendelian law involved in human genetics. It explains the idea of polygenetic inheritance and multiple allele controlling phenotypic traits in human. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Remember Shomu’s Biology is created to spread the knowledge of biology by sharing through all this biology lecture videos and animations presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman
Views: 5307 Shomu's Biology
The Inheritance of Skin Colour | Polygenic Inheritance | Post-Mendelian Genetics
 
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The inheritance of human skin colour, perfect example of Post-Mendelian Genetics (Polygenic Inheritance). Subscribe to my Channel - https://www.youtube.com/channel/UC87jSdw3F1csRFLO6u5JdeQ My Facebook - https://www.facebook.com/sabyasachi.chatterjee.9 My Instagram - https://www.instagram.com/hifromsaby/ My Linkedin - https://in.linkedin.com/in/sabyasachi-chatterjee-96045b12
Views: 1373 Sabyasachi Chatterjee
BIOLOGY HUMAN GENETICS NEET,AIIMS ,GATE ,GSCE ,BSC ,IIT JEE -MAINS,ADVANCED ,WBJEE
 
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BIOLOGY HUMAN GENETICS NEET,AIIMS ,GATE ,GSCE ,BSC ,IIT JEE -MAINS,ADVANCED ,WBJEE VISIT OUR WEBSITE https://www.souravsirclasses.com/ FOR COMPLETE LECTURES / STUDY MATERIALS /NOTES /GUIDENCE / PAST YEAR SOLVED +SAMPLE PAPAERS /TRICKS /MCQ / SHORT CUT/ VIDEO LECTURES /LIVE + ONLINE CLASSES GIVE US A CALL / WHAST APP AT 9836793076 Also find us at…. BLOGSPOT http://souravdas3366.blogspot.com/ SLIDES ON COURSES https://www.slideshare.net/Souravdas31 TWITTER https://twitter.com/souravdas3366 FACEBOOK https://www.facebook.com/Sourav-Sirs-... LINKED IN https://www.linkedin.com/in/sourav-da... GOOGLE PLUS https://plus.google.com/+souravdassou... Human genetics is the study of inheritance as it occurs in human beings. Human genetics encompasses a variety of overlapping fields including: classical genetics, cytogenetics, molecular genetics, biochemical genetics, genomics, population genetics, developmental genetics, clinical genetics, and genetic counseling. Genes can be the common factor of the qualities of most human-inherited traits. Study of human genetics can be useful as it can answer questions about human nature, understand the diseases and development of effective disease treatment, and understand genetics of human life. This article describes only basic features of human genetics; for the genetics of disorders please see: medical genetics. Genetic differences and inheritance patterns Inheritance of traits for humans are based upon Gregor Mendel's model of inheritance. Mendel deduced that inheritance depends upon discrete units of inheritance, called factors or genes Autosomal dominant inheritance Autosomal traits are associated with a single gene on an autosome (non-sex chromosome)—they are called "dominant" because a single copy—inherited from either parent—is enough to cause this trait to appear. This often means that one of the parents must also have the same trait, unless it has arisen due to an unlikely new mutation. Examples of autosomal dominant traits and disorders are Huntington's disease and achondroplasia. Autosomal recessive inheritance Autosomal recessive traits is one pattern of inheritance for a trait, disease, or disorder to be passed on through families. For a recessive trait or disease to be displayed two copies of the trait or disorder needs to be presented. The trait or gene will be located on a non-sex chromosome. Because it takes two copies of a trait to display a trait, many people can unknowingly be carriers of a disease. From an evolutionary perspective, a recessive disease or trait can remain hidden for several generations before displaying the phenotype. Examples of autosomal recessive disorders are albinism, cystic fibrosis. X-linked and Y-linked inheritance X-linked genes are found on the sex X chromosome. X-linked genes just like autosomal genes have both dominant and recessive types. Recessive X-linked disorders are rarely seen in females and usually only affect males. This is because males inherit their X chromosome and all X-linked genes will be inherited from the maternal side. Fathers only pass on their Y chromosome to their sons, so no X-linked traits will be inherited from father to son. Men cannot be carriers for recessive X linked traits, as they only have one X chromosome, so any X linked trait inherited from the mother will show up. Females express X-linked disorders when they are homozygous for the disorder and become carriers when they are heterozygous. X-linked dominant inheritance will show the same phenotype as a heterozygote and homozygote. Just like X-linked inheritance, there will be a lack of male-to-male inheritance, which makes it distinguishable from autosomal traits. One example of an X-linked trait is Coffin–Lowry syndrome, which is caused by a mutation in ribosomal protein gene. This mutation results in skeletal, craniofacial abnormalities, mental retardation, and short stature. X chromosomes in females undergo a process known as X inactivation. X inactivation is when one of the two X chromosomes in females is almost completely inactivated. It is important that this process occurs otherwise a woman would produce twice the amount of normal X chromosome proteins. The mechanism for X inactivation will occur during the embryonic stage. For people with disorders like trisomy X, where the genotype has three X chromosomes, X-inactivation will inactivate all X chromosomes until there is only one X chromosome active. Males with Klinefelter syndrome, who have an extra X chromosome, will also undergo X inactivation to have only one completely active X chromosome. Y-linked inheritance occurs when a gene, trait, or disorder is transferred through the Y chromosome. Since Y chromosomes can only be found in males, Y linked traits are only passed on from father to son. The testis determining factor, which is located on the Y chromosome, determines the maleness of individuals.
Lethal Alleles | Biology | Chegg Tutors
 
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The phenotypic manifestation of some genes is the death of the individual organism prior to sexual maturity. The factors that cause such a manifestation are called lethal alleles. A fully dominant lethal allele (i.e., one that kills in both the homozygous and heterozygous conditions) occasionally arises by mutation from a wild-type allele. Individuals with a dominant lethal allele die before they can reproduce. Therefore, the mutant dominant lethal is removed from the population in the same generation in which it arose. Lethals that kill only when homozygous may be of two kinds: (1) one that has no obvious phenotypic effect in heterozygotes, and (2) one that exhibits a distinctive phenotype when heterozygous. ---------- Biology tutoring on Chegg Tutors Learn about Biology terms like Lethal Alleles on Chegg Tutors. Work with live, online Biology tutors like Christine N. who can help you at any moment, whether at 2pm or 2am. Liked the video tutorial? Schedule lessons on-demand or schedule weekly tutoring in advance with tutors like Christine N. Visit https://www.chegg.com/tutors/Biology-online-tutoring/?utm_source=youtube&utm_medium=video&utm_content=managed&utm_campaign=videotutorials ---------- About Christine N., Biology tutor on Chegg Tutors: University of Central Florida, Class of 2018 Biomedical Sciences Major Subjects tutored: Calculus, Pre-Algebra, SAT II Biology E/M, SAT II Chemistry, Psychology, SAT II Mathematics Level 2, Writing, Biology, Chemistry, Basic Math, English as a Second Language, Sociology, SAT II Mathematics Level 1, Literature, Basic Science, Algebra, College Admissions, Pre-Calculus, Physics, English, Statistics, Study Skills, Trigonometry, Geometry, SAT, and PSAT TEACHING EXPERIENCE I have experience tutoring and teaching students from a wide range of ages. I work for a company called Aristotle Circle, where I currently lead group tutoring for AP Chemistry and have done private tutoring for pre-calculus, trigonometry, and SAT preparation. I previously had an independent tutoring job for a year working with a first and third grader on their writing and math skills. For three years, I volunteered at a kindergarten classroom and did various activities with the kids ranging from math to reading. As a result of my various experiences, I not only possess knowledge of the subjects I teach, but I am also effective at explaining the material in a way that is easy to understand. EXTRACURRICULAR INTERESTS I was born in Maryland, but I have lived most of my life in Fairfax, Virginia right outside of Washington, D.C. I am currently attending college in Florida. I love working with kids and spending time with friends and family. Want to book a private lesson with Christine N.? Message Christine N. at https://www.chegg.com/tutors/online-tutors/Christine-N-244004/?utm_source=youtube&utm_medium=video&utm_content=managed&utm_campaign=videotutorials ---------- Like what you see? Subscribe to Chegg's Youtube Channel: http://bit.ly/1PwMn3k ---------- Visit Chegg.com for purchasing or renting textbooks, getting homework help, finding an online tutor, applying for scholarships and internships, discovering colleges, and more! https://chegg.com ---------- Want more from Chegg? Follow Chegg on social media: http://instagram.com/chegg http://facebook.com/chegg http://twitter.com/chegg
Views: 15202 Chegg
Integrating Novel Advances in Gene Delivery and Genome Engineering for Therapeutic Application
 
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Presented At: LabRoots First Annual - CRISPR Virtual Events 2018 Presented By: David Schaffer, PhD - Professor of Chemical and Biomolecular Engineering, Department of Bioengineering, Director of the Berkeley Stem Cell Center, University of California at Berkeley Speaker Biography: David Schaffer is a Professor of Chemical and Biomolecular Engineering, Bioengineering, and Neuroscience at the University of California, Berkeley, where he also serves as the Director of the Berkeley Stem Cell Center. He received a B.S. in Chemical Engineering from Stanford University in 1993 and a Ph.D. in Chemical Engineering from the Massachusetts Institute of Technology in 1998. He then conducted a postdoctoral fellowship at the Salk Institute for Biological Studies before becoming a faculty member at the University of California, Berkeley in 1999. At Berkeley, Dr. Schaffer applies engineering principles to enhance stem cell and gene therapy approaches for neuroregeneration, work that includes novel approaches for molecular engineering and evolution of new viral vectors as well as new technologies to investigate and control stem cell fate decisions. Dr. Schaffer has received an NSF CAREER Award, Office of Naval Research Young Investigator Award, Whitaker Foundation Young Investigator Award, and was named a Technology Review Top 100 Innovator. He was also awarded the American Chemical Society Marvin Johnson Award in 2016, the American Chemical Society BIOT Division Young Investigator Award in 2006, the Biomedical Engineering Society Rita Shaffer Young Investigator Award in 2000, and was inducted into the College of Fellows of the American Institute of Medical and Biological Engineering in 2010. Webinar: Integrating Novel Advances in Gene Delivery and Genome Engineering for Therapeutic Application Webinar Abstract: There have been an increasing number of successful human gene therapy clinical trials, and in particular gene delivery vehicles or vectors based on the adeno-associated virus (AAV) have enabled success in trials for hemophilia B, spinal muscular atrophy, X-linked myotubular myopathy, and Leber’s congenital amaurosis type 2 (LCA2). The LCA2 trials led to the first FDA approval of a gene therapy for rare disease in the US in December, 2017. That said, vectors based on natural versions of AAV face a number of delivery challenges that limit their efficacy and will thus preclude the extension of these successes to the majority of human diseases. These delivery limitations arise since the parent viruses upon which these vectors are based were not evolved by nature for our convenience to use as human therapeutics. We have been developing and implementing a high throughput approach termed directed evolution – involving the iterative genetic diversification of a viral genome and functional selection for desired properties – to engineer highly optimized variants of AAV for a broad range of cell and tissue targets. In parallel, the advent of genome editing technologies such as the CRISPR/Cas9 system raise the possibility of using gene delivery not only for gene replacement but for repair or knockout of endogenous genes. We have thus been combining engineered AAVs with CRISPR/Cas9 for a range of applications. For example, delivery of a Cas9 targeting mutant superoxide dismutase (SOD1) in a murine model of amyotrophic lateral sclerosis delayed the onset of disease symptoms and significantly extended animal lifespan. In addition, we engineered an AAV for enhanced transport along neuronal axons, and delivery of Cas9 enabled the knockout of specific genes in vivo within projection neurons from a distance, work with both basic and translational applications. Finally, we have combined AAV delivery of donor constructs with Cas9 ribonucleoproteins to effect efficient homologous recombination within in genomic target loci. The integration of these new technologies – Cas9 cargo with AAV delivery – can thus enable a broad range of basic and therapeutic applications. Learning Objectives: 1. Adeno-associated viral vectors have the capacity to mediate efficient delivery of CRISPR/Cas9, leading to effective genome editing in vivo. 2. As a result, CRISPR/Cas9 is an effective tool to knock out autosomal dominant alleles that underlie human disease. Earn PACE/CME Credits: 1. Make sure you’re a registered member of LabRoots (https://www.labroots.com/virtual-event/crispr-2018) 2. Watch the webinar on YouTube above or on the LabRoots Website (https://www.labroots.com/virtual-event/crispr-2018) 3. Click Here to get your PACE (Expiration date – October 03, 2020 06:00 AM) – https://www.labroots.com/credit/pace-credits/3084/third-party LabRoots on Social: Facebook: https://www.facebook.com/LabRootsInc Twitter: https://twitter.com/LabRoots LinkedIn: https://www.linkedin.com/company/labroots Instagram: https://www.instagram.com/labrootsinc Pinterest: https://www.pinterest.com/labroots/ SnapChat: labroots_inc
Views: 102 LabRoots
Genetics lecture 14 | Human genetics follow non mendelian inheritance
 
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This genetics lecture explains how Human genetics follow non Mendelian inheritance genetics. It explains about polygenic inheritance and the role of multiple alleles in human inheritance biology. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Remember Shomu’s Biology is created to spread the knowledge of biology by sharing through all this biology lecture videos and animations presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman
Views: 1741 Shomu's Biology
Cystic Fibrosis: From Gene Discovery to Basic Biology to Precision Medicines
 
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The 2018 Warren Alpert Foundation Prize Symposium honors Francis Collins, Paul Negulescu, Bonnie Ramsey, Lap-Chee Tsui and Michael Welsh for pioneering contributions to the discovery of the cystic fibrosis transmembrane conductance regulator (CFTR) gene and to the subsequent research that led to the development of transformational precision medicines to treat the underlying cause of cystic fibrosis. Featured Speakers: Francis Collins, MD, PhD, Director of the National Institutes of Health Paul Negulescu, PhD, Senior Vice President of Research at Vertex Pharmaceuticals Inc. Bonnie Ramsey, MD, Endowed Chair in Cystic Fibrosis and Vice Chair of Research in the Department of Pediatrics at the University of Washington School of Medicine and Director of the Center for Clinical and Translational Research at the Seattle Children’s Hospital Research Institute Michael Welsh, MD, Professor of Internal Medicine and of Molecular Physiology and Biophysics at the University of Iowa Carver College of Medicine, Investigator at the Howard Hughes Medical Institute, and Director at the Pappajohn Biomedical Institute Pamela Davis, MD, PhD, Dean of the School of Medicine and Senior Vice President for Medical Affairs at Case Western Reserve University Jayaraj Rajagopal, MD, Professor of Medicine at Harvard Medical School, Faculty Member at the Center for Regenerative Medicine at Massachusetts General Hospital, and Faculty Scholar at the Howard Hughes Medical Institute Like Harvard Medical School on Facebook: https://goo.gl/4dwXyZ Follow on Twitter: https://goo.gl/GbrmQM Follow on Instagram: https://goo.gl/s1w4up Follow on LinkedIn: https://goo.gl/04vRgY Website: https://hms.harvard.edu/